75 drugs reach their earliest generic-entry date in 2029

Jan 2029 · 5

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Lamictal Xr · 6 strengths lamotrigine	lamotrigine	Glaxosmithkline Llc	022115	7 Jan 2029	patent
Janumet · 2 strengths metformin hydrochloride; sitagliptin phosphate	metformin hydrochloride; sitagliptin phosphate	Msd Sub Merck	022044	21 Jan 2029	patent
Angiomax bivalirudin	bivalirudin	Sandoz	020873	27 Jan 2029	patent
Noxafil Powdermix Kit posaconazole	posaconazole	Msd Merck Co	214770	27 Jan 2029	exclusivity
Lymphoseek Kit technetium tc-99m tilmanocept	technetium tc-99m tilmanocept	Cardinal Health 414	202207	30 Jan 2029	patent

Feb 2029 · 5

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Lo Loestrin Fe ethinyl estradiol; norethindrone acetate	ethinyl estradiol; norethindrone acetate	Apil	022501	2 Feb 2029	patent, carve-out possible
Actoplus Met metformin hydrochloride; pioglitazone hydrochloride	metformin hydrochloride; pioglitazone hydrochloride	Takeda Pharms Usa	021842	3 Feb 2029	patent
Vyzulta latanoprostene bunod	latanoprostene bunod	Bausch And Lomb	207795	21 Feb 2029	patent
Zipsor diclofenac potassium	diclofenac potassium	Cosette	022202	24 Feb 2029	patent, carve-out possible
Finacea azelaic acid	azelaic acid	Leo Pharma As	207071	28 Feb 2029	patent, carve-out possible

Mar 2029 · 11

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Bromsite bromfenac sodium	bromfenac sodium	Sun Pharm	206911	5 Mar 2029	patent
Quartette ethinyl estradiol; levonorgestrel	ethinyl estradiol; levonorgestrel	Teva Branded Pharm	204061	11 Mar 2029	patent
Nitrolingual Pumpspray nitroglycerin	nitroglycerin	Pohl Boskamp	018705	12 Mar 2029	patent
Tiglutik Kit riluzole	riluzole	Italfarmaco Sa	209080	12 Mar 2029	patent
Raldesy trazodone hydrochloride	trazodone hydrochloride	Kamat	218637	13 Mar 2029	patent
Tudorza Pressair aclidinium bromide	aclidinium bromide	Azurity	202450	13 Mar 2029	patent
Sirturo · 2 strengths bedaquiline fumarate	bedaquiline fumarate	Janssen Therap	204384	19 Mar 2029	patent
Jakafi · 5 strengths ruxolitinib phosphate	ruxolitinib phosphate	Incyte Corp	202192	22 Mar 2029	exclusivity
Nucynta Er · 5 strengths tapentadol hydrochloride	tapentadol hydrochloride	Collegium Pharm Inc	200533	22 Mar 2029	patent
Karbinal Er carbinoxamine maleate	carbinoxamine maleate	Aytu	022556	29 Mar 2029	patent
Remodulin · 5 strengths treprostinil	treprostinil	United Therap	021272	29 Mar 2029	patent

Apr 2029 · 2

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Brisdelle paroxetine mesylate	paroxetine mesylate	Legacy	204516	6 Apr 2029	patent
Nulibry fosdenopterin hydrobromide	fosdenopterin hydrobromide	Sentynl Theraps Inc	214018	9 Apr 2029	patent

May 2029 · 4

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Vidaza azacitidine	azacitidine	Bristol-Myers	050794	20 May 2029	exclusivity
Mitosol mitomycin	mitomycin	Glaukos	022572	21 May 2029	patent, carve-out possible
Kazano · 2 strengths alogliptin benzoate; metformin hydrochloride	alogliptin benzoate; metformin hydrochloride	Takeda Pharms Usa	203414	24 May 2029	patent
Zioptan tafluprost	tafluprost	Thea Pharma	202514	28 May 2029	patent

Jun 2029 · 11

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Rasuvo · 9 strengths methotrexate	methotrexate	Medexus	205776	1 Jun 2029	patent, carve-out possible
Verkazia cyclosporine	cyclosporine	Harrow Eye	214965	2 Jun 2029	patent
Oseni · 4 strengths alogliptin benzoate; pioglitazone hydrochloride	alogliptin benzoate; pioglitazone hydrochloride	Takeda Pharms Usa	022426	4 Jun 2029	patent
Horizant · 2 strengths gabapentin enacarbil	gabapentin enacarbil	Azurity	022399	10 Jun 2029	patent
Nicorette · 2 strengths nicotine polacrilex	nicotine polacrilex	Haleon Us Holdings	022360	14 Jun 2029	patent
Qsymia · 4 strengths phentermine hydrochloride; topiramate	phentermine hydrochloride; topiramate	Vivus Llc	022580	14 Jun 2029	patent, carve-out possible
Nesina · 3 strengths alogliptin benzoate	alogliptin benzoate	Takeda Pharms Usa	022271	16 Jun 2029	patent
Rexulti brexpiprazole	brexpiprazole	Otsuka	205422	23 Jun 2029	patent
Inomax nitric oxide	nitric oxide	Mallinckrodt Ireland	020845	30 Jun 2029	patent
Trelstar triptorelin pamoate	triptorelin pamoate	Verity	022437	30 Jun 2029	patent
Triptodur Kit triptorelin pamoate	triptorelin pamoate	Azurity	208956	30 Jun 2029	patent

Jul 2029 · 8

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Valchlor mechlorethamine hydrochloride	mechlorethamine hydrochloride	Helsinn	202317	8 Jul 2029	patent, carve-out possible
Rukobia fostemsavir tromethamine	fostemsavir tromethamine	Viiv Hlthcare	212950	13 Jul 2029	patent
Diacomit · 2 strengths stiripentol	stiripentol	Biocodex Sa	206709	14 Jul 2029	exclusivity
Diacomit · 2 strengths stiripentol	stiripentol	Biocodex Sa	207223	14 Jul 2029	exclusivity
Tylenol With Naproxen acetaminophen; naproxen sodium	acetaminophen; naproxen sodium	Kenvue Brands	219962	24 Jul 2029	exclusivity
Xifaxan · 2 strengths rifaximin	rifaximin	Salix Pharms	021361	24 Jul 2029	patent, carve-out possible
Zokinvy · 2 strengths lonafarnib	lonafarnib	Sentynl Theraps Inc	213969	26 Jul 2029	patent, carve-out possible
Gwyn Lo ethinyl estradiol; norelgestromin	ethinyl estradiol; norelgestromin	Viatris Specialty	219990	28 Jul 2029	exclusivity

Aug 2029 · 6

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Acanya benzoyl peroxide; clindamycin phosphate	benzoyl peroxide; clindamycin phosphate	Bausch	050819	5 Aug 2029	patent
Onexton benzoyl peroxide; clindamycin phosphate	benzoyl peroxide; clindamycin phosphate	Bausch	050819	5 Aug 2029	patent
Acuvail ketorolac tromethamine	ketorolac tromethamine	Abbvie	022427	15 Aug 2029	patent
Mydayis · 4 strengths amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate	amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate	Takeda Pharms Usa	022063	24 Aug 2029	patent
Invokamet Xr · 4 strengths canagliflozin; metformin hydrochloride	canagliflozin; metformin hydrochloride	Janssen Pharms	205879	26 Aug 2029	patent
Invokana · 2 strengths canagliflozin	canagliflozin	Janssen Pharms	204042	26 Aug 2029	patent

Sep 2029 · 7

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Isentress raltegravir potassium	raltegravir potassium	Msd Sub Merck	203045	11 Sep 2029	patent
Isentress raltegravir potassium	raltegravir potassium	Msd Sub Merck	205786	11 Sep 2029	patent
Kyleena levonorgestrel	levonorgestrel	Bayer Hlthcare	208224	16 Sep 2029	patent, carve-out possible
Mirena levonorgestrel	levonorgestrel	Bayer Hlthcare	021225	16 Sep 2029	patent, carve-out possible
Skyla levonorgestrel	levonorgestrel	Bayer Hlthcare	203159	16 Sep 2029	patent, carve-out possible
Tykerb lapatinib ditosylate	lapatinib ditosylate	Novartis	022059	18 Sep 2029	patent
Savella · 4 strengths milnacipran hydrochloride	milnacipran hydrochloride	Abbvie	022256	19 Sep 2029	patent, carve-out possible

Oct 2029 · 5

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Varubi rolapitant hydrochloride	rolapitant hydrochloride	Tersera	206500	9 Oct 2029	patent
Travatan Z travoprost	travoprost	Sandoz	021994	13 Oct 2029	patent
Vivitrol naltrexone	naltrexone	Alkermes	021897	15 Oct 2029	patent, carve-out possible
Opsumit macitentan	macitentan	Actelion	204410	18 Oct 2029	patent
Ferriprox deferiprone	deferiprone	Chiesi	208030	26 Oct 2029	patent

Nov 2029 · 6

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Auvi-Q epinephrine	epinephrine	Kaleo Inc	201739	2 Nov 2029	patent
Xalkori · 2 strengths crizotinib	crizotinib	Pf Prism Cv	202570	6 Nov 2029	patent
Xalkori · 3 strengths crizotinib	crizotinib	Pf Prism Cv	217581	6 Nov 2029	patent
Ninlaro · 3 strengths ixazomib citrate	ixazomib citrate	Takeda Pharms Usa	208462	20 Nov 2029	patent
Iomervu · 4 strengths iomeprol	iomeprol	Bracco	216016	27 Nov 2029	exclusivity
Iomervu · 4 strengths iomeprol	iomeprol	Bracco	216017	27 Nov 2029	exclusivity

Dec 2029 · 5

Drug	Ingredient	Applicant	NDA	Earliest generic entry	Basis
Namzaric · 4 strengths donepezil hydrochloride; memantine hydrochloride	donepezil hydrochloride; memantine hydrochloride	Abbvie	206439	5 Dec 2029	patent, carve-out possible
Ofev · 2 strengths nintedanib esylate	nintedanib esylate	Boehringer Ingelheim	205832	7 Dec 2029	patent
Zyclara imiquimod	imiquimod	Bausch	022483	11 Dec 2029	patent, carve-out possible
Zepzelca lurbinectedin	lurbinectedin	Jazz	213702	13 Dec 2029	patent
Triesence triamcinolone acetonide	triamcinolone acetonide	Harrow Eye	022048	17 Dec 2029	patent